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Abstract
Growth Performance, Lipid Deposition and Hepatic Lipid Metabolism Related Gene Expression in Schizothorax prenanti fed with Dietary Acidolysis-Oxidized Konjac Glucomannan Supplementation
Mingrui Chen, Yinglong Wu, Qiuping Yan, Zhenzhen Lv, Mei He, Limei Feng, Jiaqi Zhao and Zhengxin Duan
The present study was conducted to investigate the effects of dietary acidolysis-oxidized konjac glucomannan (A-OKGM) (0, 0.4, 0.8 and 1.6%) supplementation on the growth performance, lipid metabolism of Schizothorax prenanti, a commonly cultured freshwater fish in inland China. The 1.6% A-OKGM diet significantly improved weight gain (WG) (P<0.05). Triglycerides (TG) content in both serum and liver was significantly increased when diets supplemented with A-OKGM, regardless of inclusion level (P<0.05). The total cholesterol (TC) and LDL-cholesterol (LDL-C) levels in serum were significantly increased when fish fed with 0.4%, 1.6% A-OKGM diets (P<0.05). However, only 1.6% A-OKGM diet significantly increased HDL-cholesterol (HDL-C) level (P<0.05). Dietary 1.6% A-OKGM supplementation had a significant effect on glucose level in the serum (P<0.05). However, the activities of phosphoenolpyruvate carboxykinase (PEPCK) and hexokinase (HK) were significantly decreased by both 0.8% and 1.6% A-OKGM diets (P<0.05). A-OKGM diets significantly affected glucose-6-phosphate dehydrogenase (G6PD) and total lipase activity of Schizothorax prenanti, regardless of inclusion level (P<0.05). The lipid content in the liver was significantly increased by A-OKGM diets, regardless of inclusion level (P<0.05). Moreover, A-OKGM diets significantly up-regulated the mRNA levels of lipogenic genes (PPARγ, FAS, ACCa, FABP, GPDH and HMGCR), regardless of inclusion level (P<0.05). The expression of CPT1 in fish fed with 1.6% A-OKGM diet was significantly lower than that of control group (P<0.05). These results encourage conducting further research on the administration of A-OKGM and other prebiotics in Schizothorax prenanti.