Biochemistry & Analytical Biochemistry

Abstract

Fluorescent Synthetic Receptors for Signaling Hydrogen Sulphide in Living Systems

Kaloo MA, Shah WA, Bhat BA and Gani M

In this work, we have compiled literature wherein various attempts regarding design and development of abiotic molecular receptors amid fluorescent signaling response for selective detection of various sulphur species (H₂S, HS^-, SO₃^2- S^2-) in living cells has been presented. We have specifically compiled the literature which presents the molecular systems deciphering the real-time potential for targeting mentioned chemical species under biological conditions or living cells. With regard to the chemical aspects of designed receptors, focus has been primarily diverted towards interaction of analyte with the receptor molecule at active site. The interaction driven output as a result of electronic modulation in the molecule has been discussed besides detection limit of the analyte. In addition to all this, we have also summarized the conditions for tracking of various Sulphur species in biosystems. The proposed receptors from the literature have been categorized into five classes depending on the mechanism of encounter between analyte and receptor molecule responsible for fluorescence signaling.

Published Date: 2019-01-21; Received Date: 2019-01-04