Mustafa ZAKARIA, Mohamed ZARQAOUI, Noureddine LOUANJLI, Nisrine EN-NACIRI, Mohamed ENNAJI, Amal KABIT, Naima EL-YOUSFI, Romaissa BOUTICHE
The main effects of insulin resistance in the pathogenesis of PCOS, strategies to reduce insulin and improve reproductive parameters in PCOS patients and should be recommended for all overweight and obese patients, and the effects of insulin resistance on the results of IVF or sperm injection were examined. Intracytoplasmic (ICSI) in women with PCOS. Insulin sensitivity was measured by continuous glucose infusion with a form evaluation test (CIGMA). Insulin-resistant (n=26) and non-insulin-resistant (n=30) women with PCOS underwent a total of 100 cycles of long-term down-regulation with poserilin acetate, stimulation with recombinant human FSH, and IVF or ICSI. And the ovarian stimulation period for hormone tests. The insulin-resistant and non-insulin-resistant women had similar concentrations of FSH, LH, testosterone, and androstenedione during stimulation, but the insulin-resistant women had hyperinsulinemia and low concentrations of globulin associated with sex hormones. The insulin-resistant women also had low concentrations of estradiol during stimulation and required higher FSH doses, but these differences disappeared after controlling for higher body weight in the insulin-resistant group of women. Insulin resistance was neither associated with hormone levels nor with IVF outcomes. Obesity, regardless of insulin resistance, is associated with relative gonadal resistance, necessary to confirm these findings. In conclusion, it has been shown that reducing insulin resistance improves the ovulation rate in PCOS patients, but there is strong evidence to maintain the usefulness of insulin-causing drugs as a treatment option.
Published Date: 2020-11-23; Received Date: 2020-10-21