This review presents an overview of the multi targets of the duloxetine drug which was a product of the famous Eli Lilly Company. Although there is little evidence that the studies reproduce, it is clear that different transmitters or receptor types are involved in hyperalgesia and chronic pain which duloxetine mainly targets. While most attention has been focused on neuro transmitters and serotonin-norepinephrine reuptake mechanisms proving the drug efficacy in most discussed aspects. It is mainly known to work by raising the quantity of natural substances, serotonin and norepinephrine in the brain that helps maintaining the mental balance and pause the movement of pain signals in the brain. Any how the side effects are never correlated with the misusage of the drug dosage.