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Abstract
Determination of Fragrance Allergens in Essential Oils and Evaluation of their in vitro Permeation from Essential Oil Formulations through Cultured Skin
Lai-Hao Wang and Hung-Jiun Liu
We developed a high-performance liquid chromatography method using fl uorometric detection to simultaneously determine the allergens in fragrances, primarily structurally related allylbenzenes in essential oils. The effect of essential oil carriers—cloves, basil, and cinnamon—on the release and percutaneous absorption of the oils was studied in vitro using a cultured epidermal autograft membrane model.