Journal of Biomolecular Research & Therapeutics

Abstract

Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides

Miruka Conrad Ondieki, Matunda Conradus Nyaribari, Nnamdi John Ejekwumadu and Mokembo Justin Nyakang’o

The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex was also predicted using bioinformatics tools.