Brain Disorders & Therapy

Abstract

Deep Brain Stimulation for Alzheimer's Disease

Angelo Lavano, Attilio Della Torre, Giusy Guzzi, Federica Deodato, Francesco Lavano and Giorgio Volpentesta

Alzheimer?s disease (AD) is a debilitating neurological illness of increasing prevalence. Accumulations of abnormal proteins (beta amyloid and tau protein), inflammatory cascades, abnormal responses to oxidative stress and alteration in oxidative metabolism have been implicated in AD. There are few therapeutic options available for this disorder. Latest research indicates that deep brain stimulation (DBS) may be a method for improving cognitive functions. Many aspects remain unclear, particularly with regard to the optimal target structure. In this review the pathophysiology, neural circuitry and potential neuromodulation options in patients with AD are resumed.