Periodontal diseases are inflammatory conditions and many forms of the disease are associated with specific pathogenic bacteria, which colonize the subgingival area. However, the presence of bacteria itself is not capable of producing advanced tissue destruction in all individuals. Initiation and progression of periodontal infections are modified by local and systemic conditions, which defined as risk factors. Systemic risk factors include diabetes mellitus, smoking, age and genetic factors. Recent studies also pointed out to several potentially important risk indicators such as psychosocial factors; stress, depression and ineffective coping, state and trait anxiety. The aim of the present paper is to review the association between psychosocial factors and periodontal disease.