Farhana Ferdousi, Mohammad Abdul Hai Siddique, Syed Muhammad Kamaluddin, Muhammad Saiedullah and Liaquat Ali
Dyslipidemia and subclinical inflammation are the major determinants of cardiovascular disorders. For the management of dyslipidemia, statin is used and claimed to be effective in the reduction subclinical inflammation. In this study, lipidemic and subclinical inflammatory status in patients treated with stable statin (atorvastatin) therapy were evaluated in 111 Bangladeshi subjects. Lipid parameters and marker of subclinical inflammation (hsCRP) were measured by enzymatic endpoint techniques and by immunoturbidimetric method. Persistent single dyslipidemia is prominent for low-density lipoprotein (LDL) cholesterol (57.66%), followed by hypertriglyceridemia (55.86%), high-density lipoprotein (HDL) cholesterol dyslipidemia (54.06%), and hypercholesterolemia (20.72%). Regarding combined lipid abnormalities, elevated triglyceride (TG) combined with elevated LDL cholesterol was most frequent (35.13%). Persistent multiple combined lipid abnormalities for 3 lipid parameters (low HDL cholesterol, elevated LDL cholesterol and elevated TG) was observed for 19.82% subjects. Persistent subclinical inflammation (hsCRP > 3.0 mg/l) was found to be high (36.94%), followed by moderate risk (33.33%) and low risk for CVDs (29.73%). hsCRP showed positive association total cholesterol (TC) and negative association with LDL cholesterol and HDL cholesterol. But after adjustment for age, sex, BMI, diabetes mellitus and duration of statin therapy, only HDL cholesterol showed significant inverse association with hsCRP (?=- 0.314, p = 0.016). This study revealed that single or multiple combined dyslipidemia persists in subjects treated with statin. Large proportions of the subjects had subclinical inflammation which is inversely associated with HDL cholesterol on adjusting confounders.
