jdm

Journal of Diabetes & Metabolism

ISSN - 2155-6156

Abstract

Association of Alpha-2 Beta-1 Integrin Polymorphism with Retinopathy in Diabetic Patients

Nadeem Afzal, Nagi AH, Muhammad Imran, Abu Zafar, Amtul Musawar, Romeeza Tahir, Sarwar Abbas, Afia Abbas, Shakeela Zaman and Shah Jahan

Aim: Diabetes mellitus (DM) is a health concern because it leads to complications such as retinopathy and nephropathy. Pakistan has 6.9 million DM affected people that will be doubled by 2025. A study was designed to determine the role of genetics in diabetic retinopathy in Pakistani type 2 diabetes mellitus (T2DM) patients.

Material and methods: It was a cross-sectional case-control study that included 236 subjects, divided into Group I (54 volunteers without diabetes), Group II (30 T2DM patients without retinopathy) and Group III (152 T2DM patients with retinopathy). A BglII polymorphism of α2β1 integrin gene was genotyped in all these individuals by using RFLP method.

Results: The frequency of BglII polymorphism (++ and +-) genotypes was found significantly different between group I and group III individuals.

Conclusion: BglII (+/+, +/-) genotypes, gender of subject, age at the onset of diabetes, and duration of diabetes is associated with development of diabetic retinopathy in Pakistani T2DM patients.

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