Oral Health and Dental Management

Abstract

Assessment of Salivary MDA and Antioxidant Vitamins in Patients with Erosive Type of Oral Lichen Planus and Lichenoid Reaction

Atefeh Tavangar, Parichehr Ghalayani, Milad Alikhani, Narjes Amrollahi

Background: oral Lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology. Reduced level of antioxidant and oxidative stress is implicated in pathogenesis of OLP. Methods: 80 patients (40 OLP patients and 40 OLR patients), were included in this cross sectional study and compared with 40 normal subjects. Unstimulated whole saliva (UWS) was collected and vitamin A, E, C and MDA (malondealdehyde) concentrations were measured using human Elisa kits. One way variances, ANOVA and post hoc were used to analyze the data (SPSS ver. 18) (α=0.05). Results: Mean levels of vitamin A antioxidants in OLP (0.16 ± 0.06 Nmol/mg)and OLR(0.14 ± 0.05 Nmol/mg) patients were significantly lower than those of the control group(0.54 ± 0.20 Nmol/mg) (P value<0.001). mean levels of vitamin E antioxidants only in OLP patients(7/82 ± 2.94 Nmol/mg) were significantly lower than those of the control group(10.80 ± 4.40)( P value=0.03).but with no difference in mean level of vitamin C between two groups and with control group (P value=0.619). There wasn’t any significant difference in mean level of MDA between OLP patients (2.46 ± 1.21 Nmol/mg), OLR patients (2.53 ± 1.36 Nmol/mg) and control group (2.62 ± 1.15 Nmol/mg) (P value=0.925). Conclusion: Considering the results of the present study and reported role of antioxidant deficiency and oxidative stress in OLP and OLR pathogenesis, measurement of salivary vitamins (A, E, C) and MDA concentrations may help in treatment planning and preventive strategies.