Biochemistry & Analytical Biochemistry

Abstract

Antioxidant Potential of Phycobiliproteins: Role in Anti-Aging Research

Ravi Raghav Sonani, Rajesh Prasad Rastogi and Datta Madamwar*

Aging research has made significant progress over recent years, particularly after the formulation of ‘Oxidative stress theory of aging’. According to this theory, aging and its associated abnormalities may be prevented, at least to some extent, by application of certain antioxidants. Cyanobacterial phycobiliproteins (PBPs), the major light harvesting pigment proteins are widely characterized for their in vivo and in vitro antioxidant activity. Since, reactive oxygen species (ROS) are considered as important factors to cause aging, PBPs can be used as an effective free radical scavengers and be a potent candidate to develop the anti-aging drug. The use of PBPs in preventing the oxidative stress mediated abnormalities or aging is rationally debated. The present review enlightens the recent advances in the field of antioxidant function of PBPs and major challenges in the application of these pigment proteins in anti-aging research. Also included is the possible mechanism behind the anti-aging capacity of these ecologically as well as economically important biomolecules.